I use them right now in my 60 cube, just because my sump is rather small... and yes, cleaning them sucks monkeyballs.. the cleaning, swapping constantly, etc..
In my 150 I'm building now, I had two custom bubble towers made, and pondering on putting some pieces of rubble in there to help cut down on bubbles.... I do not plan on running socks this time around, because they are a pain in the rear. The worst part is, when the color starts to change from white to dark, it's time to change the darn things. If you don't do it quick enough, I believe they are a nitrate trap!
No sock for me on this new tank.