I have a giant 55w pond UV sterilizer bazooka. I originally got it to fight dinos and it did a good job. I kept it on for over a year after being dino-free and turned it off to see if there would be any difference. Honestly, I can't say there is. I don't see any more or less algae or more or less fish getting ich. I'm keeping it off for now because it raised my water temp by 1-2 degrees being on all the time and i think it helped in eradicating all traces of amphipods from my system. I would always find amphipods in the outlets and I figured their dwindling population was caused by the UV hindering their reproduction. Didn't really do anything to benthic copepods or other life, just the palegic types that will swim in the water column and get caught in the pump.
So I'm not really sure if it helps or not. It definitely did help with dinos but once I got rid of those I'm not sure it helps with anything else.
Also, depending on what you're doing, the two most important factors when getting a UV is getting one that is the right size for whatever it is you are trying to do as well as getting a pump with flow that is slow enough for longer exposure to the UV. You're not going to do anything with those mini/compact UV toys that they sell for cheap. I basically just use an MJ1200 for my 55w which is approx. 300gph.
http://www.drsfostersmith.com/pic/article.cfm?aid=440
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